Main Difference – Protonation vs Deprotonation Protonation and deprotonation are important chemical reactions in the synthesis of different chemical compounds. Protonation is the addition of a proton to a chemical species. Deprotonation is the removal of a proton from a chemical compound.  The main difference between protonation and deprotonation is that protonation adds a +1 … Continue reading Difference Between Protonation and Deprotonation